ABSTRACT
Abstract Purpose: To investigate the therapeutic potential of human immature dental pulp stem cells in the treatment of chronic spinal cord injury in dogs. Methods: Three dogs of different breeds with chronic SCI were presented as animal clinical cases. Human immature dental pulp stem cells were injected at three points into the spinal cord, and the animals were evaluated by limb function and magnetic resonance imaging (MRI) pre and post-operative. Results: There was significant improvement from the limb function evaluated by Olby Scale, though it was not supported by the imaging data provided by MRI and clinical sign and evaluation. Conclusion: Human dental pulp stem cell therapy presents promising clinical results in dogs with chronic spinal cord injuries, if used in association with physical therapy.
Subject(s)
Humans , Animals , Dogs , Spinal Cord Injuries/veterinary , Stem Cell Transplantation/veterinary , Dental Pulp/cytology , Dog Diseases/therapy , Spinal Cord Injuries/therapy , Magnetic Resonance Imaging , Chronic Disease , Treatment Outcome , Recovery of Function , Stem Cell Transplantation/methodsABSTRACT
Foram analisadas 528 radiografias simples de fraturas de rádio e ulnado arquivo do Serviço de Diagnostico por Imagem do Departamentode Cirurgia junto ao Hospital Veterinário da Faculdade de MedicinaVeterinária e Zootecnia da Universidade de São Paulo realizadas noperíodo de julho de 1999 a dezembro de 2005, selecionando-se osmeses para análise de forma randomizada. Os principais resultadosencontrados foram: Fraturas de rádio e ulna representam 20,9% dototal encontradas, destas o tipo mais observado foi a transversal,tanto no rádio (75,5%) quanto na ulna (76,6%). 87,1% das fraturasacometeram o rádio e a ulna. O terço distal foi o mais acometido foio distal, tanto do rádio quanto da ulna (72,9% e 70,1%,respectivamente). Esquírolas ósseas foram observadas em 13,8% edesvio de eixo ósseo em 94,9% dos casos. 40,2% dos cães nãopossuíam raça definida. 34,3% dos cães possuíam idade entre seismeses a um ano.
Survey of 528 radiographs of radius and ulna fractures selected fromarchive of Radiology Service of the Surgery Department into theVeterinary Hospital of Veterinary College of the University of SaoPaulo from July 1999 December 2005 we randomly selected themonths to analyze. Radius and ulna fractures represent 20.9% oftotal fractures. 87.1% of these fractures attacked both bones.Transversal fractures were the most common type even in radius(75.5%) than ulna (76.6%), which occurred mainly at distal third radius(72.9%) and ulna (70.1%). Mix-breed dogs (40.2%), between theages of six months and one year (34.3%), with displacement of axisbone (94.9%) were the most frequent types observed.